Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease
Identifieur interne : 001415 ( Main/Exploration ); précédent : 001414; suivant : 001416Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease
Auteurs : Ronald B. Postuma [Canada] ; Dag Aarsland [Norvège] ; Paolo Barone [Italie] ; David J. Burn [Royaume-Uni] ; Christopher H. Hawkes [Royaume-Uni] ; Wolfgang Oertel [Allemagne] ; Tjalf Ziemssen [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2012-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Biomarkers, Early Diagnosis, Humans, Motor Neurons (metabolism), Motor Neurons (pathology), Motor system disorder, Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Prediction, Prodrome, Sensitivity, Specificity, non‐motor, prediction, sensitivity, specificity.
- MESH :
- chemical : Biomarkers.
- diagnosis : Parkinson Disease.
- metabolism : Motor Neurons, Parkinson Disease.
- pathology : Motor Neurons, Parkinson Disease.
- physiopathology : Parkinson Disease.
- Early Diagnosis, Humans.
Abstract
Increasing recognition that Parkinson's disease (PD) may start outside of the substantia nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor signs permit classical diagnosis. Many of these efforts center around the identification of clinical non‐motor symptoms and signs of disease. There is now direct evidence that olfaction, rapid eye movement (REM) sleep behavior disorder (RBD), constipation, and depression can be present in prodromal PD. In addition, there is suggestive evidence that visual changes, other autonomic symptoms, and subtle cognitive changes may also be present at prodromal stages. A critical issue in utility of these prodromal markers will be assessment of sensitivity, specificity, and positive and negative predictive values. Although these have yet to be fully defined, olfactory deficits, some visual changes, and autonomic symptoms occur in the majority of PD patients at diagnosis, suggesting good potential sensitivity. However, with the exception of RBD and perhaps some specific autonomic measures, specificity, and positive predictive value of these markers may be insufficient to be used alone as identifiers of prodromal disease. The evidence for the utility of olfaction, RBD, autonomic markers, visual changes, mood disorders, and cognitive loss as markers of prodromal PD and the potential sensitivity and specificity of these markers are summarized. © 2012 Movement Disorder Society
Url:
DOI: 10.1002/mds.24996
Affiliations:
- Allemagne, Canada, Italie, Norvège, Royaume-Uni
- Angleterre, District de Dresde, District de Giessen, Grand Londres, Hesse (Land), Québec, Saxe (Land)
- Dresde, Londres, Marbourg, Montréal
- Université McGill, Université technique de Dresde
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Le document en format XML
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Many of these efforts center around the identification of clinical non‐motor symptoms and signs of disease. There is now direct evidence that olfaction, rapid eye movement (REM) sleep behavior disorder (RBD), constipation, and depression can be present in prodromal PD. In addition, there is suggestive evidence that visual changes, other autonomic symptoms, and subtle cognitive changes may also be present at prodromal stages. A critical issue in utility of these prodromal markers will be assessment of sensitivity, specificity, and positive and negative predictive values. Although these have yet to be fully defined, olfactory deficits, some visual changes, and autonomic symptoms occur in the majority of PD patients at diagnosis, suggesting good potential sensitivity. However, with the exception of RBD and perhaps some specific autonomic measures, specificity, and positive predictive value of these markers may be insufficient to be used alone as identifiers of prodromal disease. The evidence for the utility of olfaction, RBD, autonomic markers, visual changes, mood disorders, and cognitive loss as markers of prodromal PD and the potential sensitivity and specificity of these markers are summarized. © 2012 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Dresde</li><li>District de Giessen</li><li>Grand Londres</li><li>Hesse (Land)</li><li>Québec</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li><li>Londres</li><li>Marbourg</li><li>Montréal</li></settlement><orgName><li>Université McGill</li><li>Université technique de Dresde</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></region><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></country><country name="Norvège"><noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name></noRegion><name sortKey="Hawkes, Christopher H" sort="Hawkes, Christopher H" uniqKey="Hawkes C" first="Christopher H." last="Hawkes">Christopher H. Hawkes</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name></region><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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